The pilot in command is responsible for ensuring compliance with which of the following?

The pilot in command holds the overarching responsibility for the safety and compliance of flight operations. This includes ensuring adherence to regulations such as AFI 11-202, Volume 3, which provides guidance on general flight rules and responsibilities for military aviation. Additionally, compliance with MAJCOM (Major Command) guidance is crucial, as this outlines specific policies that govern flight operations within a particular command's jurisdiction.

Understanding that the pilot's duties encompass a broader range of responsibilities is key. The pilot must not only comply with local regulations but also navigate the intricate set of rules and protocols established at higher organizational levels. This includes maintaining safety standards, checking weather conditions, and monitoring NOTAMs (notices to airmen), but these responsibilities fall under the broader umbrella of ensuring overall compliance with established aviation regulations and directives.

In contrast, focusing solely on local regulations, flight safety protocols, or only on weather and NOTAM reports would neglect the full scope of the pilot in command’s duties and responsibilities, which include the comprehensive governance set forth in the AFI and MAJCOM guidelines. Therefore, option B accurately captures the essence of a pilot's responsibility by highlighting the need for compliance with essential flight regulations and commands.